To verify the contents of the gas system at factories that comply with GMP (Good Manufacturing Practice), a complete gas analysis should be carried out at least once a year. This is especially important in cases where the gas comes into contact with the finished product.
For example, in the GMP guide for APIs (Active Pharmaceutical Ingredient) issued by the International Conference on Harmonization (ICH), Q7 §7.31 states that complete analysis should be carried out at appropriate intervals (i.e. at least once a year). Analysis services from Linde are specially developed for manufacturers of finished pharmaceuticals and APIs who use gas distribution systems in their manufacturing processes.
Many Linde specialty gases laboratories offer both standardised analyses in accordance with the requirements of European and US Pharmacopoeias and individualised gas analysis services.