Liquid Chromatography - Mass Spectrometry (LC-MS) is a powerful analytical technique used in industries requiring very low detection limits of sometimes unknown samples, such as food analysis and pharmaceutical drug development. The efficient physical separation of chemical substances dissolved in a mobile phase, performed by liquid chromatography, is combined with the mass spectrometer being able to sort and identify the components (gaseous ions) in electric and magnetic fields according to their mass-to-charge ratios. The samples analysed by LC-MS are often complex mixtures.
Detection limit |
Gas recommendation |
Regulator recommendation |
Gas generator recommendation |
Collision cell gas | |||
≤ 1 ppm | HiQ Argon 6.0 | REDLINE C200 series | n/a |
≤ 1 ppm | HiQ Helium 6.0 | REDLINE C200 series | n/a |
≤ 1 ppm | HiQ Nitrogen 6.0 | REDLINE C200 series | n/a |
Nebuliser gas | |||
≤ 1 ppm | HiQ Nitrogen 4.6 | BASELINE C106 series | HiQ LC/MS Nitrogen |
Curtain gas (Atmospheric Pressure Ionisation) | |||
≤ 1 ppm | HiQ Nitrogen 4.6 | BASELINE C106 series | HiQ N2-MISTRAL Hydrid LC/MS |
Exhaust gas (Atmospheric Pressure Ionisation) | |||
≤ 1 ppm | HiQ Air 4.0 | BASELINE C106 series | HiQ N2-MISTRAL Hydrid LC/MS |
≤ 1 ppm | HiQ Nitrogen 4.6 | BASELINE C106 series | HiQ N2-MISTRAL Hydrid LC/MS |
Source gas (Atmospheric Pressure Ionisation) | |||
≤ 1 ppm | HiQ Air 4.0 | BASELINE C106 series | HiQ N2-MISTRAL Hydrid LC/MS |
≤ 1 ppm | HiQ Nitrogen 4.6 | BASELINE C106 series | HiQ N2-MISTRAL Hydrid LC/MS |